Never had any problems with it. And we used it on everything from big cats to primates. We even used it on hoofstock crocodile. It was wonderful for crocodile. Never had any problems with it. But of course, sertraline is PCP angel dust, and became a controlled substance and they finally stopped making it. But it was one of the best anesthetic agents that we ever had to use in zoo animal medicine. They put a derivative called ketamine on the market and it was all right, but not like sertraline.